The normal androgen receptor and some mutations associated with androgen resistance.
The numbers in parentheses show the amino-acid position of the mutations. Triangles denote single amino-acid substitutions, asterisks termination codons. The two mutations marked in the colour ovals are both present in a single family. The segments indicated by A and B show the approximate positions of gene deletions in two families. Modified from JE Griffin ( 1992) by courtesy of New England Journal of Medicine.